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KMID : 1134820000290010168
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 1 p.168 ~ p.173
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Effect of Green Tea on Mixed Function Oxidase System and Xanthine Oxidase Activities in Rat Liver Exposed to Microwaves
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Lee Yong-Hee
Rhee Soon-Jae
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Abstract
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The purpose of this study was to investigate the changes of microsomal mixed function oxidase (MFO) and xanthine oxidase activities (XOD) in the liver of rats exposed to microwave. Sprague-Dawley male rats weighing 200±10 g body weight were randomly assigned to a normal and microwave exposed (MW) groups; microwave exposed groups were divided into two groups; microwave (MW) group and green tea (GT) group which were fed distilled water and green tea extracts during experimentl periods, respectively. Rats were irradiated with microwave at the frequenecy of 2.45 GHz for 15min and rats were sacrificed at the 4th day of the microwave irradiation. The hemoglobin level of GT group was higher than that of the normal group and MW group, but the hematocrit value was not significantly different among all experimental groups. The activity of serum GOT of MW group was significantly increased but that of GT group was similar to normal group. Activities of GPT were not significantly different among all experimental groups. Liver XOD activity was significantly increased in the microwave exposed groups but green tea normalized the XOD activity. The activity of hepatic microsomal cytochrome P_(450) was significantly increased in MW group compared to normal group and that of GT group was similar to that of the normal group. The activity of hepatic microsomal NADPH-cytochrome P_(450) reductase was also significantly increased in MW group compared to normal group, but that of GT group was similar to that of the normal group. In conclusion, the activities of MFO and XOD were elevated by microwave irradiation, but the activation of MFO system as well as the damage of the liver by microwave were reduced by green tea supplementation.
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KEYWORD
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microwave, mixed function oxidase, xanthine oxidase
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